Research workbench
Crystal structure of human 4E10 Fab crystalized in the presence of phosphatidylcholine (06:0 pc); I422 space group
Analyse Crystal structure of human 4E10 Fab crystalized in the presence of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XCC
- Type
- protein
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4E10 Fab light chain; 4E10 Fab heavy chain
- Pockets
- 5 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | 4E10 Fab light chain | protein | 214 | 7% helix, 50% strand | — |
| H | 4E10 Fab heavy chain | protein | 226 | 5% helix, 52% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · chains L, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 366 | 0.55 | 0.74 | 42 | empty |
| 2 | 117 | 0.48 | 0.80 | 28 | empty |
| 3 | 212 | 0.48 | 0.75 | 35 | empty |
| 4 | 141 | 0.47 | 0.78 | 22 | empty |
| 5 | 92 | 0.34 | 0.73 | 22 | empty |
Interfaces
1 interface between chains.
- L–H · 1560 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4XCC · Crystal structure of human 4E10 Fab crystalized in the presence of Phosphatidylcholine… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4XCC · PDBe 4XCC
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