Research workbench
Structure of feruloyl-CoA 6-hydroxylase (F6H) from arabidopsis thaliana
Analyse Structure of feruloyl-CoA 6-hydroxylase (F6H) from arabidopsis thaliana in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XAE
- Type
- protein
- Length
- 653 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Feruloyl CoA ortho-hydroxylase 1
- EC
- 1.14.11.-
- UniProt
- Q9LHN8
- Ligands
- NA
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Feruloyl CoA ortho-hydroxylase 1 (EC 1.14.11.-) | protein | 329 | 32% helix, 19% strand | Q9LHN8 |
| B | Feruloyl CoA ortho-hydroxylase 1 (EC 1.14.11.-) | protein | 324 | 31% helix, 19% strand | Q9LHN8 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.70 | 0.79 | 63 | NA |
| 2 | 480 | 0.67 | 0.78 | 57 | NA |
| 3 | 51 | 0.37 | 0.80 | 17 | empty |
| 4 | 96 | 0.36 | 0.75 | 25 | empty |
| 5 | 70 | 0.30 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 257 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 4XAE · Structure of Feruloyl-CoA 6-hydroxylase (F6H) from Arabidopsis thaliana · the same entry in another collection · chain A against A, TM-score 1.00
- Q9LHN8 · AlphaFold monomer V2.0 prediction for feruloyl CoA ortho-hydroxylase 1 (Q9LHN8) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9LHN8
- Elsewhere: RCSB PDB 4XAE · PDBe 4XAE · UniProt Q9LHN8
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