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Crystal structure of a chimeric murine norovirus NS6 protease (inactive C139A mutant) in which the P4-P4 prime residues of the cleavage junction in the extended C-terminus have been replaced by the corresponding residues from the NS2-3 junction.

Analyse Crystal structure of a chimeric murine norovirus NS6 protease (inactive C139A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4X2Y
Type: protein
Length: 347 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NS6 PROTEASE,NS6 protease
UniProt: Q80J95
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NS6 PROTEASE,NS6 protease	protein	172	3% helix, 48% strand	Q80J95
B	NS6 PROTEASE,NS6 protease	protein	175	5% helix, 49% strand	Q80J95

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	131	0.66	0.88	25	empty

Interfaces

1 interface between chains.

A–B · 539 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4X2Y · Crystal structure of a chimeric Murine Norovirus NS6 protease (inactive C139A mutant) in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q80J95
Elsewhere: RCSB PDB 4X2Y · PDBe 4X2Y · UniProt Q80J95

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