Research workbench
Clostridium difficile wild type fic protein
Analyse Clostridium difficile wild type fic protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4X2E
- Type
- protein
- Length
- 797 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fic family protein putative filamentation induced by camp protein
- UniProt
- C9YJ22
- Pockets
- 9 · best druggability 0.64
Structure
x-ray diffraction · 4 distinct chains · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fic family protein putative filamentation induced by camp protein | protein | 201 | 62% helix, 1% strand | C9YJ22 |
| B | Fic family protein putative filamentation induced by camp protein | protein | 203 | 64% helix, 1% strand | C9YJ22 |
| C | Fic family protein putative filamentation induced by camp protein | protein | 200 | 62% helix, 2% strand | C9YJ22 |
| D | Fic family protein putative filamentation induced by camp protein | protein | 193 | 63% helix, 2% strand | C9YJ22 |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.64 | 0.77 | 48 | empty |
| 2 | 107 | 0.38 | 0.75 | 18 | empty |
| 3 | 62 | 0.36 | 0.77 | 11 | empty |
| 4 | 87 | 0.35 | 0.75 | 21 | empty |
| 5 | 98 | 0.34 | 0.73 | 11 | empty |
Interfaces
4 interfaces between chains.
- A–B · 391 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 40 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 36 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 30 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4X2E · Clostridium difficile wild type Fic protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C9YJ22
- Elsewhere: RCSB PDB 4X2E · PDBe 4X2E · UniProt C9YJ22
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