Research workbench

Nuclear transport factor 2 (NTF2) E42K mutant

Analyse Nuclear transport factor 2 (NTF2) E42K mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1AR0
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear transport factor 2
UniProt: P61972
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear transport factor 2	protein	125	28% helix, 47% strand	P61972
B	Nuclear transport factor 2	protein	121	29% helix, 50% strand	P61972

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	185	0.44	0.74	30	empty

Interfaces

1 interface between chains.

A–B · 1322 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1AR0 · Nuclear transport factor 2 (NTF2) E42K mutant · the same entry in another collection · chain A against A, TM-score 1.00
P61972 · AlphaFold monomer V2.0 prediction for nuclear transport factor 2 (P61972) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61972
Elsewhere: RCSB PDB 1AR0 · PDBe 1AR0 · UniProt P61972

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