Research workbench
Crystal structure of human TCR alpha chain-TRAV21-TRAJ8 and beta chain-TRBV7-8
Analyse Crystal structure of human TCR alpha chain-TRAV21-TRAJ8 and beta chain-TRBV7-8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WW1
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TCR alpha chain-TRAV21-TRAJ8; TCR beta chain-TRBV7-8
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TCR alpha chain-TRAV21-TRAJ8 | protein | 197 | 5% helix, 49% strand | — |
| B | TCR beta chain-TRBV7-8 | protein | 241 | 7% helix, 49% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 944 | 0.71 | 0.75 | 94 | empty |
| 2 | 79 | 0.36 | 0.76 | 23 | empty |
| 3 | 50 | 0.33 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2097 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 4WW1 · Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8 and Beta Chain-TRBV7-8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4WW1 · PDBe 4WW1
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