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Crystal structure of the mimivirus polyadenylate synthase

Analyse Crystal structure of the mimivirus polyadenylate synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4WSE
Type: protein
Length: 990 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative POLY(A) polymerase catalytic subunit
EC: 2.7.7.19
UniProt: Q5UQS6
Pockets: 17 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative POLY(A) polymerase catalytic subunit (EC 2.7.7.19)	protein	495	45% helix, 18% strand	Q5UQS6
B	Putative POLY(A) polymerase catalytic subunit (EC 2.7.7.19)	protein	495	45% helix, 20% strand	Q5UQS6

Pockets

17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1055	0.82	0.83	95	empty
2	941	0.78	0.81	78	empty
3	273	0.68	0.83	30	empty
4	310	0.64	0.80	38	empty
5	162	0.61	0.84	25	empty

Interfaces

1 interface between chains.

A–B · 3434 Å² buried · 40 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4WSE · Crystal structure of the Mimivirus polyadenylate synthase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5UQS6
Elsewhere: RCSB PDB 4WSE · PDBe 4WSE · UniProt Q5UQS6

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