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Crystal structure and functional analysis of MID49, a receptor for the mitochondrial fission protein DRP1

Analyse Crystal structure and functional analysis of MID49, a receptor for the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4WOY
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial dynamics protein MID49
UniProt: Q5NCS9
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mitochondrial dynamics protein MID49	protein	329	44% helix, 18% strand	Q5NCS9

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	594	0.74	0.81	39	empty
2	603	0.72	0.80	52	empty
3	309	0.64	0.80	39	empty
4	94	0.52	0.84	24	empty
5	64	0.50	0.85	23	empty

Interfaces

1 interface between chains.

A–B · 286 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4WOY · Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial… · the same entry in another collection · chain A against A, TM-score 1.00
Q5NCS9 · AlphaFold monomer V2.0 prediction for mitochondrial dynamics protein MID49 (Q5NCS9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5NCS9
Elsewhere: RCSB PDB 4WOY · PDBe 4WOY · UniProt Q5NCS9

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