Crystal structure of the tpr domain of lgn in complex with FRMPD4/PRESO1 at 1.5 ångström resolution

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Ligands and binding sites

• SCN · Thiocyanate ion · ion · 7 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 6 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 5 copies · chains A, B
• PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1822 Ų buried · 38 hydrogen bonds · protein-protein

Compared structures

• 4WND · Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 1.5 Angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
• P81274 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (P81274) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q14CM0 · AlphaFold monomer V2.0 prediction for ferm and PDZ domain-containing protein 4 (Q14CM0) · a predicted model of the same protein · chain B against A, TM-score 0.30

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P81274
• Every structure of UniProt Q14CM0
• Elsewhere: RCSB PDB 4WND · PDBe 4WND · UniProt P81274 · UniProt Q14CM0