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Crystal structure of the gmp synthetase from plasmodium falciparum

Analyse Crystal structure of the gmp synthetase from plasmodium falciparum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4WIM
Type: protein
Length: 1,000 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gmp synthetase
EC: 6.3.5.2
UniProt: Q8IJR9
Pockets: 17 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gmp synthetase (EC 6.3.5.2)	protein	520	33% helix, 16% strand	Q8IJR9
B	Gmp synthetase (EC 6.3.5.2)	protein	480	35% helix, 11% strand	Q8IJR9

Pockets

17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	940	0.82	0.83	106	empty
2	702	0.79	0.83	110	empty
3	514	0.77	0.84	63	empty
4	96	0.77	0.97	30	empty
5	490	0.75	0.83	58	empty

Interfaces

1 interface between chains.

A–B · 1152 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4WIM · Crystal Structure of the GMP Synthetase from Plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IJR9
Elsewhere: RCSB PDB 4WIM · PDBe 4WIM · UniProt Q8IJR9

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