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Structure of artocarpin: a lectin with mannose specificity (form 2)

Analyse Structure of artocarpin: a lectin with mannose specificity (form 2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1J4T
Type: protein
Length: 1,192 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Artocarpin
UniProt: Q7M1T4
Pockets: 2 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 64% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Artocarpin	protein	149	0% helix, 64% strand	Q7M1T4

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	362	0.84	0.93	51	empty
2	580	0.82	0.87	80	empty

Interfaces

12 interfaces between chains.

C–D · 959 Å² buried · 14 hydrogen bonds · protein-protein
G–H · 950 Å² buried · 15 hydrogen bonds · protein-protein
E–F · 940 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 925 Å² buried · 17 hydrogen bonds · protein-protein
E–G · 760 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (nonstandard).

Compared structures

1J4T · Structure of Artocarpin: a Lectin with Mannose Specificity (Form 2) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7M1T4
Elsewhere: RCSB PDB 1J4T · PDBe 1J4T · UniProt Q7M1T4

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