Research workbench
Fab fragment of mouse AZ130 monoclonal antibody
Analyse Fab fragment of mouse AZ130 monoclonal antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WCY
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AZ130 heavy chain; AZ130 light chain
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | AZ130 heavy chain | protein | 210 | 6% helix, 54% strand | — |
| L | AZ130 light chain | protein | 217 | 6% helix, 53% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.66 | 0.75 | 58 | GOL |
| 2 | 77 | 0.53 | 0.86 | 22 | empty |
| 3 | 96 | 0.35 | 0.74 | 17 | empty |
| 4 | 74 | 0.31 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- H–L · 1735 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4WCY · Fab fragment of mouse AZ130 monoclonal antibody · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4WCY · PDBe 4WCY
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