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Crystal structure analysis of the FKBP12 complexed with 000107 small molecule

Analyse Crystal structure analysis of the FKBP12 complexed with 000107 small molecule in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1J4H
Type: protein
Length: 107 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FKBP12
EC: 5.2.1.8
UniProt: P62942
Ligands: SUB
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	FKBP12 (EC 5.2.1.8)	protein	107	10% helix, 39% strand	P62942

Ligands and binding sites

SUB · 3-phenyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-propionic acid ethyl ester · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.38	0.76	13	SUB

Compared structures

1J4H · crystal structure analysis of the FKBP12 complexed with 000107 small molecule · the same entry in another collection · chain A against A, TM-score 1.00
P62942 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP1A (P62942) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62942
Elsewhere: RCSB PDB 1J4H · PDBe 1J4H · UniProt P62942

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