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Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link

Analyse Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4V3M
Type: protein
Length: 658 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pleurotolysin a; Pleurotolysin B
UniProt: Q8X1M9, Q5W9E8
Pockets: 2 · best druggability 0.35

Structure

electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Pleurotolysin a	protein	135	0% helix, 0% strand	Q8X1M9
C	Pleurotolysin B	protein	388	0% helix, 0% strand	Q5W9E8

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.35	0.73	34	empty
2	68	0.32	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 134 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4V3M · Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8X1M9
Every structure of UniProt Q5W9E8
Elsewhere: RCSB PDB 4V3M · PDBe 4V3M · UniProt Q8X1M9 · UniProt Q5W9E8

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