Research workbench
Membrane embedded pleurotolysin pore with 13 fold symmetry
Analyse Membrane embedded pleurotolysin pore with 13 fold symmetry in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4V2T
- Type
- protein
- Length
- 9,673 residues
- Chains
- 39
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pleurotolysin a; Pleurotolysin B
- UniProt
- Q8X1M9, Q5W9E8
- Pockets
- 20 · best druggability 0.47
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0, 2, 3, 5, 6, 8, 9, B, C, E, F, H, I, K, L, N, O, Q, R, T, U, W, X, Z, b, c | Pleurotolysin a | protein | 135 | 0% helix, 0% strand | Q8X1M9 |
| 1, 4, 7, D, G, J, M, P, S, V, Y, a | Pleurotolysin B | protein | 474 | 0% helix, 0% strand | Q5W9E8 |
| A | Pleurotolysin B | protein | 475 | 0% helix, 0% strand | Q5W9E8 |
Pockets
20 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.47 | 0.73 | 49 | empty |
| 2 | 133 | 0.41 | 0.73 | 41 | empty |
| 3 | 124 | 0.40 | 0.73 | 34 | empty |
| 4 | 112 | 0.40 | 0.73 | 35 | empty |
| 5 | 97 | 0.37 | 0.73 | 30 | empty |
Interfaces
26 interfaces between chains.
- J–M · 503 Ų buried · 0 hydrogen bonds · protein-protein
- 7–a · 502 Ų buried · 0 hydrogen bonds · protein-protein
- 1–Y · 502 Ų buried · 0 hydrogen bonds · protein-protein
- D–G · 502 Ų buried · 0 hydrogen bonds · protein-protein
- S–V · 502 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4V2T · Membrane embedded pleurotolysin pore with 13 fold symmetry · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8X1M9
- Every structure of UniProt Q5W9E8
- Elsewhere: RCSB PDB 4V2T · PDBe 4V2T · UniProt Q8X1M9 · UniProt Q5W9E8
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