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FLRT3 lrr domain

Analyse FLRT3 lrr domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4V2E
Type: protein
Length: 642 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibronectin leucine rich transmembrane protein 3
UniProt: Q8BGT1
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fibronectin leucine rich transmembrane protein 3	protein	321	5% helix, 18% strand	Q8BGT1

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	897	0.76	0.80	72	empty
2	338	0.55	0.75	34	empty

Interfaces

1 interface between chains.

A–B · 1329 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

4V2E · FLRT3 LRR domain · the same entry in another collection · chain A against A, TM-score 1.00
Q8BGT1 · AlphaFold monomer V2.0 prediction for leucine-rich repeat transmembrane protein FLRT3… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BGT1
Elsewhere: RCSB PDB 4V2E · PDBe 4V2E · UniProt Q8BGT1

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