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The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669)
Analyse The crystal structure of mouse PP1G in complex with truncated human PPP1R15B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4V0W
- Type
- protein
- Length
- 623 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase 1…
- EC
- 3.1.3.16
- UniProt
- P63087, Q5SWA1
- Ligands
- MN
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit (EC 3.1.3.16) | protein | 295 | 34% helix, 20% strand | P63087 |
| B | Protein phosphatase 1 regulatory subunit 15B | protein | 16 | 0% helix, 44% strand | Q5SWA1 |
| C | SERINE/THREONINE-protein phosphatase PP1-gamma catalytic subunit (EC 3.1.3.16) | protein | 290 | 34% helix, 20% strand | P63087 |
| D | Protein phosphatase 1 regulatory subunit 15B | protein | 22 | 0% helix, 32% strand | Q5SWA1 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 4 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.61 | 0.82 | 34 | empty |
| 2 | 214 | 0.61 | 0.81 | 33 | empty |
| 3 | 195 | 0.51 | 0.77 | 24 | empty |
| 4 | 162 | 0.47 | 0.76 | 23 | empty |
| 5 | 152 | 0.45 | 0.76 | 24 | MN |
Interfaces
3 interfaces between chains.
- C–D · 1327 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1029 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 815 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4V0W · The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669) · the same entry in another collection · chain D against D, TM-score 1.00
- P63087 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-gamma… · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q5SWA1 · AlphaFold monomer V2.0 prediction for protein phosphatase 1 regulatory subunit 15B… · a predicted model of the same protein · chain B against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63087
- Every structure of UniProt Q5SWA1
- Elsewhere: RCSB PDB 4V0W · PDBe 4V0W · UniProt P63087 · UniProt Q5SWA1
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