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Crystal structure of apical membrane antigen 1 from plasmodium knowlesi

Analyse Crystal structure of apical membrane antigen 1 from plasmodium knowlesi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4UV6
Type: protein
Length: 672 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apical merozoite antigen 1
UniProt: B3L5E1
Pockets: 7 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Apical merozoite antigen 1	protein	336	20% helix, 26% strand	B3L5E1
B	Apical merozoite antigen 1	protein	336	19% helix, 26% strand	B3L5E1

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	537	0.67	0.77	48	empty
2	234	0.65	0.83	27	empty
3	152	0.47	0.77	20	empty
4	85	0.46	0.81	23	empty
5	72	0.32	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 848 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

4UV6 · Crystal structure of apical membrane antigen 1 from Plasmodium knowlesi · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B3L5E1
Elsewhere: RCSB PDB 4UV6 · PDBe 4UV6 · UniProt B3L5E1

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