Research workbench
Apo trichomonas vaginalis lactate dehydrogenase
Analyse Apo trichomonas vaginalis lactate dehydrogenase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UUM
- Type
- protein
- Length
- 671 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate dehydrogenase
- EC
- 1.1.1.27
- UniProt
- O96445
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 334 | 47% helix, 19% strand | O96445 |
| B | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 337 | 47% helix, 19% strand | O96445 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 785 | 0.73 | 0.78 | 76 | empty |
| 2 | 499 | 0.65 | 0.77 | 39 | empty |
| 3 | 389 | 0.62 | 0.77 | 44 | empty |
| 4 | 312 | 0.62 | 0.79 | 36 | empty |
| 5 | 130 | 0.47 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1654 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 4UUM · Apo trichomonas vaginalis lactate dehydrogenase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O96445
- Elsewhere: RCSB PDB 4UUM · PDBe 4UUM · UniProt O96445
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