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Crystal structure of the scfv fragment of the broadly neutralizing human antibody EDE2 A11
Analyse Crystal structure of the scfv fragment of the broadly neutralizing human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UT7
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Broadly neutralizing human antibody EDE2 A11
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Broadly neutralizing human antibody EDE2 A11 | protein | 146 | 10% helix, 41% strand | — |
| L | Broadly neutralizing human antibody EDE2 A11 | protein | 113 | 7% helix, 50% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.34 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- H–L · 1174 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4UT7 · Crystal structure of the scfv fragment of the broadly neutralizing human antibody EDE2 A11 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4UT7 · PDBe 4UT7
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