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Electron cryo-microscopy of venezuelan equine encephalitis virus tc- 83 in complex with neutralizing antibody Fab F5
Analyse Electron cryo-microscopy of venezuelan equine encephalitis virus tc- 83 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UOM
- Type
- protein
- Length
- 422 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab fragment heavy chain; Fab fragment light chain
- Pockets
- 2 · best druggability 0.69
Structure
electron microscopy · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab fragment heavy chain | protein | 217 | 7% helix, 52% strand | — |
| L | Fab fragment light chain | protein | 205 | 5% helix, 41% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 767 | 0.69 | 0.76 | 80 | empty |
| 2 | 75 | 0.37 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- H–L · 1830 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4UOM · Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC- 83 in complex with… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4UOM · PDBe 4UOM
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