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Electron cryo-microscopy of venezuelan equine encephalitis virus tc-83 in complex with neutralizing antibody Fab 3B4C-4

Analyse Electron cryo-microscopy of venezuelan equine encephalitis virus tc-83 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4UOK
Type: protein
Length: 433 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab fragment heavy chain; Fab fragment light chain
Pockets: 5 · best druggability 0.52

Structure

electron microscopy · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fab fragment heavy chain	protein	218	11% helix, 48% strand	—
L	Fab fragment light chain	protein	215	7% helix, 53% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.52	0.77	36	empty
2	99	0.35	0.74	19	empty
3	50	0.33	0.78	16	empty
4	74	0.32	0.74	19	empty
5	71	0.31	0.74	22	empty

Interfaces

1 interface between chains.

A–L · 1750 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4UOK · Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC-83 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4UOK · PDBe 4UOK

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