Research workbench
Crystal structure of the receiver domain of cpxr from E. COLI (orthorhombic form)
Analyse Crystal structure of the receiver domain of cpxr from E. COLI (orthorhombic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UHJ
- Type
- protein
- Length
- 373 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulatory protein cpxr
- UniProt
- P0AE88
- Ligands
- MG
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcriptional regulatory protein cpxr | protein | 126 | 48% helix, 18% strand | P0AE88 |
| C | Transcriptional regulatory protein cpxr | protein | 121 | 47% helix, 18% strand | P0AE88 |
Ligands and binding sites
- MG · Magnesium ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.66 | 0.85 | 28 | empty |
| 2 | 156 | 0.56 | 0.82 | 20 | empty |
| 3 | 140 | 0.51 | 0.80 | 22 | empty |
| 4 | 131 | 0.49 | 0.79 | 23 | empty |
| 5 | 73 | 0.29 | 0.73 | 21 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1334 Ų buried · 32 hydrogen bonds · protein-protein
- A–B · 462 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4UHJ · Crystal structure of the receiver domain of CpxR from E. coli (orthorhombic form) · the same entry in another collection · chain A against A, TM-score 1.00
- P0AE88 · AlphaFold monomer V2.0 prediction for transcriptional regulatory protein cpxr (P0AE88) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE88
- Elsewhere: RCSB PDB 4UHJ · PDBe 4UHJ · UniProt P0AE88
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.