Research workbench
N-terminal globular domain of the rsv nucleoprotein in complex with C-terminal dipeptide of the phosphoprotein
Analyse N-terminal globular domain of the rsv nucleoprotein in complex with C-terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UC9
- Type
- protein
- Length
- 880 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein
- UniProt
- P03418
- Ligands
- SO4
- Pockets
- 15 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 62% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 221 | 62% helix, 9% strand | P03418 |
| B | Nucleoprotein | protein | 221 | 61% helix, 9% strand | P03418 |
| C | Nucleoprotein | protein | 223 | 61% helix, 9% strand | P03418 |
| D | Nucleoprotein | protein | 215 | 63% helix, 7% strand | P03418 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 7 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1033 | 0.78 | 0.80 | 103 | SO4 |
| 2 | 131 | 0.51 | 0.80 | 19 | empty |
| 3 | 161 | 0.42 | 0.74 | 25 | empty |
| 4 | 78 | 0.41 | 0.79 | 16 | empty |
| 5 | 97 | 0.41 | 0.77 | 18 | empty |
Interfaces
6 interfaces between chains.
- A–D · 647 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 501 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 446 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 238 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 109 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4UC9 · N-terminal globular domain of the RSV Nucleoprotein in complex with C- terminal dipeptide… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03418
- Elsewhere: RCSB PDB 4UC9 · PDBe 4UC9 · UniProt P03418
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