Research workbench
Crystal structure of translocator protein 18KDA (tspo) from rhodobacter sphaeroides (A139T mutant) in P212121 space group
Analyse Crystal structure of translocator protein 18KDA (tspo) from rhodobacter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UC2
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translocator protein tspo
- UniProt
- Q9RFC8
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translocator protein tspo | protein | 156 | 74% helix, 0% strand | Q9RFC8 |
| B | Translocator protein tspo | protein | 155 | 75% helix, 0% strand | Q9RFC8 |
Ligands and binding sites
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 6 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 217 | 0.72 | 0.87 | 33 | empty |
| 2 | 175 | 0.66 | 0.85 | 29 | OLC |
Interfaces
1 interface between chains.
- A–B · 1271 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4UC2 · Crystal structure of translocator protein 18kDa (TSPO) from rhodobacter sphaeroides… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9RFC8 · AlphaFold monomer V2.0 prediction for tryptophan-rich sensory protein (Q9RFC8) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RFC8
- Elsewhere: RCSB PDB 4UC2 · PDBe 4UC2 · UniProt Q9RFC8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.