Research workbench
Inactive structure of histidine kinase
Analyse Inactive structure of histidine kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4U7N
- Type
- protein
- Length
- 423 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine protein kinase sensor protein
- UniProt
- C6VIM1
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histidine protein kinase sensor protein | protein | 211 | 48% helix, 23% strand | C6VIM1 |
| B | Histidine protein kinase sensor protein | protein | 212 | 48% helix, 23% strand | C6VIM1 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 190 | 0.52 | 0.77 | 24 | empty |
| 2 | 66 | 0.50 | 0.85 | 20 | empty |
| 3 | 77 | 0.42 | 0.80 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1274 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4U7N · Inactive structure of histidine kinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6VIM1
- Elsewhere: RCSB PDB 4U7N · PDBe 4U7N · UniProt C6VIM1
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