Research workbench
Crystal structure of a complex of the MIZ1- and NAC1 poz domains.
Analyse Crystal structure of a complex of the MIZ1- and NAC1 poz domains. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4U2N
- Type
- protein
- Length
- 465 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger and btb domain-containing protein 17,NUCLEUS accumbens-associated protein 1
- UniProt
- Q13105, Q96RE7
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger and btb domain-containing protein 17,NUCLEUS accumbens-associated protein 1 | protein | 230 | 53% helix, 14% strand | Q13105, Q96RE7 |
| B | Zinc finger and btb domain-containing protein 17,NUCLEUS accumbens-associated protein 1 | protein | 235 | 52% helix, 13% strand | Q13105, Q96RE7 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 562 | 0.64 | 0.75 | 66 | empty |
| 2 | 178 | 0.54 | 0.79 | 23 | empty |
| 3 | 164 | 0.53 | 0.79 | 20 | empty |
| 4 | 69 | 0.32 | 0.75 | 18 | empty |
| 5 | 52 | 0.30 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 285 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4U2N · Crystal structure of a complex of the Miz1- and Nac1 POZ domains. · the same entry in another collection · chain A against A, TM-score 1.00
- Q96RE7 · AlphaFold monomer V2.0 prediction for nucleus accumbens-associated protein 1 (Q96RE7) · a predicted model of the same protein · chain A against A, TM-score 0.48
- Q13105 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 17… · a predicted model of the same protein · chain B against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13105
- Every structure of UniProt Q96RE7
- Elsewhere: RCSB PDB 4U2N · PDBe 4U2N · UniProt Q13105 · UniProt Q96RE7
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