Research workbench
Crystal structure of a complex of the MIZ1- and BCL6 poz domains.
Analyse Crystal structure of a complex of the MIZ1- and BCL6 poz domains. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4U2M
- Type
- protein
- Length
- 941 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger and btb domain-containing protein 17,B-cell lymphoma 6 protein
- UniProt
- Q13105, P41182
- Pockets
- 12 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger and btb domain-containing protein 17,B-cell lymphoma 6 protein | protein | 228 | 54% helix, 12% strand | Q13105, P41182 |
| B | Zinc finger and btb domain-containing protein 17,B-cell lymphoma 6 protein | protein | 240 | 52% helix, 16% strand | Q13105, P41182 |
| C | Zinc finger and btb domain-containing protein 17,B-cell lymphoma 6 protein | protein | 233 | 55% helix, 15% strand | Q13105, P41182 |
| D | Zinc finger and btb domain-containing protein 17,B-cell lymphoma 6 protein | protein | 240 | 55% helix, 13% strand | Q13105, P41182 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.77 | 0.79 | 106 | empty |
| 2 | 275 | 0.66 | 0.83 | 34 | empty |
| 3 | 514 | 0.62 | 0.75 | 36 | empty |
| 4 | 313 | 0.52 | 0.73 | 25 | empty |
| 5 | 129 | 0.50 | 0.80 | 21 | empty |
Interfaces
6 interfaces between chains.
- C–D · 695 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 647 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 554 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 301 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 142 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4U2M · Crystal structure of a complex of the Miz1- and BCL6 POZ domains. · the same entry in another collection · chain A against A, TM-score 1.00
- Q13105 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 17… · a predicted model of the same protein · chain B against A, TM-score 0.42
- P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13105
- Every structure of UniProt P41182
- Elsewhere: RCSB PDB 4U2M · PDBe 4U2M · UniProt Q13105 · UniProt P41182
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