Research workbench
Structure of C. elegans htp-1 bound to htp-3 motif-1
Analyse Structure of C. elegans htp-1 bound to htp-3 motif-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4TZQ
- Type
- protein
- Length
- 496 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein htp-1; Protein htp-3
- UniProt
- Q20305, O01820
- Pockets
- 4 · best druggability 0.35
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein htp-1 | protein | 233 | 31% helix, 27% strand | Q20305 |
| B, D | Protein htp-3 | protein | 13 | 0% helix, 77% strand | O01820 |
| C | Protein htp-1 | protein | 237 | 30% helix, 28% strand | Q20305 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.35 | 0.74 | 21 | empty |
| 2 | 77 | 0.33 | 0.74 | 14 | empty |
| 3 | 58 | 0.29 | 0.74 | 13 | empty |
| 4 | 54 | 0.26 | 0.74 | 20 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1111 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1032 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 64 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 34 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 31 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4TZQ · Structure of C. elegans HTP-1 bound to HTP-3 motif-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q20305
- Every structure of UniProt O01820
- Elsewhere: RCSB PDB 4TZQ · PDBe 4TZQ · UniProt Q20305 · UniProt O01820
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