Research workbench

Crystal structure of translation initiation factor 5A from pyrococcus horikoshii

Analyse Crystal structure of translation initiation factor 5A from pyrococcus horikoshii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IZ6
Type: protein
Length: 407 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Initiation factor 5A
UniProt: O50089
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Initiation factor 5A	protein	136	7% helix, 54% strand	O50089
C	Initiation factor 5A	protein	135	5% helix, 56% strand	O50089

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	194	0.55	0.79	39	empty
2	72	0.32	0.75	18	empty

Interfaces

1 interface between chains.

B–C · 565 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1IZ6 · Crystal Structure of Translation Initiation Factor 5A from Pyrococcus Horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
O50089 · AlphaFold monomer V2.0 prediction for translation initiation factor 5A (O50089) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O50089
Elsewhere: RCSB PDB 1IZ6 · PDBe 1IZ6 · UniProt O50089

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.