Research workbench

Pyrococcus furiosus PCNA mutant (MET73LEU, ASP143ALA, ASP147ALA): orthorhombic form

Analyse Pyrococcus furiosus PCNA mutant (MET73LEU, ASP143ALA, ASP147ALA): orthorhombic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IZ5
Type: protein
Length: 480 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen
UniProt: O73947
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Proliferating cell nuclear antigen	protein	240	17% helix, 48% strand	O73947

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.77	0.99	18	empty
2	60	0.76	0.99	17	empty
3	54	0.32	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 989 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

1IZ5 · Pyrococcus furiosus PCNA mutant (Met73Leu, Asp143Ala, Asp147Ala): orthorhombic form · the same entry in another collection · chain A against A, TM-score 1.00
O73947 · AlphaFold monomer V2.0 prediction for DNA polymerase sliding clamp (O73947) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O73947
Elsewhere: RCSB PDB 1IZ5 · PDBe 1IZ5 · UniProt O73947

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.