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Dimeric structure of fih (factor inhibiting hif)

Analyse Dimeric structure of fih (factor inhibiting hif) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IZ3
Type: protein
Length: 338 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fih
UniProt: Q9NWT6
Ligands: SO4
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fih	protein	338	31% helix, 25% strand	Q9NWT6

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	419	0.67	0.79	43	empty
2	140	0.52	0.80	26	empty
3	121	0.40	0.75	24	empty
4	114	0.37	0.74	23	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

1IZ3 · Dimeric structure of FIH (Factor inhibiting HIF) · the same entry in another collection · chain A against A, TM-score 1.00
Q9NWT6 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha inhibitor (Q9NWT6) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NWT6
Elsewhere: RCSB PDB 1IZ3 · PDBe 1IZ3 · UniProt Q9NWT6

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