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Structure of a lysozyme antibody complex

Analyse Structure of a lysozyme antibody complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4TSB
Type: protein
Length: 558 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysozyme C; Fab heavy chain; Fab light chain
EC: 3.2.1.17
UniProt: P00698
Pockets: 6 · best druggability 0.57

Structure

x-ray diffraction · 3 distinct chains · 15% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysozyme C (EC 3.2.1.17)	protein	129	40% helix, 11% strand	P00698
H	Fab heavy chain	protein	215	7% helix, 51% strand	—
L	Fab light chain	protein	214	7% helix, 50% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	435	0.57	0.74	58	empty
2	225	0.52	0.77	27	empty
3	170	0.48	0.77	27	empty
4	110	0.39	0.75	24	empty
5	51	0.31	0.77	19	empty

Interfaces

3 interfaces between chains.

H–L · 1738 Å² buried · 18 hydrogen bonds · protein-protein
A–H · 494 Å² buried · 10 hydrogen bonds · protein-protein
A–L · 387 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

4TSB · Structure of a lysozyme antibody complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00698
Elsewhere: RCSB PDB 4TSB · PDBe 4TSB · UniProt P00698

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