Research workbench

Covalent complex of E. COLI transaldolase talb with tagatose-6- phosphate

Analyse Covalent complex of E. COLI transaldolase talb with tagatose-6- phosphate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4S2B
Type: protein
Length: 632 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transaldolase B
EC: 2.2.1.2
UniProt: P0A870
Ligands: 44S, SO4
Pockets: 5 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transaldolase B (EC 2.2.1.2)	protein	316	56% helix, 13% strand	P0A870

Ligands and binding sites

44S · 2-deoxy-6-O-phosphono-beta-D-lyxo-hexofuranose · ligand · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	171	0.82	0.97	26	empty
2	112	0.46	0.79	21	44S
3	114	0.43	0.77	20	44S
4	56	0.29	0.75	12	empty
5	53	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 823 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

4S2B · Covalent complex of E. coli transaldolase TalB with tagatose-6-phosphate · the same entry in another collection · chain A against A, TM-score 1.00
P0A870 · AlphaFold monomer V2.0 prediction for transaldolase B (P0A870) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A870
Elsewhere: RCSB PDB 4S2B · PDBe 4S2B · UniProt P0A870

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.