Research workbench
Crystal structure of HA2-del-L2SEM, central coiled-coil from influenza hemagglutinin HA2 without heptad repeat stutter
Analyse Crystal structure of HA2-del-L2SEM, central coiled-coil from influenza… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4S1X
- Type
- protein
- Length
- 194 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Truncated hemagglutinin
- UniProt
- A8TXJ0
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 94% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Truncated hemagglutinin | protein | 38 | 95% helix, 0% strand | A8TXJ0 |
| B, E | Truncated hemagglutinin | protein | 37 | 95% helix, 0% strand | A8TXJ0 |
| C, F | Truncated hemagglutinin | protein | 22 | 91% helix, 0% strand | A8TXJ0 |
Ligands and binding sites
- GOL · Glycerol · additive · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.48 | 0.75 | 21 | empty |
| 2 | 59 | 0.31 | 0.75 | 12 | empty |
Interfaces
8 interfaces between chains.
- D–E · 777 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 767 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 625 Ų buried · 2 hydrogen bonds · protein-protein
- D–F · 601 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 346 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 4S1X · Crystal structure of HA2-Del-L2seM, Central Coiled-Coil from Influenza Hemagglutinin HA2… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8TXJ0
- Elsewhere: RCSB PDB 4S1X · PDBe 4S1X · UniProt A8TXJ0
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