Research workbench
Crystal structure of T. brucei farnesyl diphosphate synthase
Analyse Crystal structure of T. brucei farnesyl diphosphate synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RYP
- Type
- protein
- Length
- 698 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyl pyrophosphate synthase
- UniProt
- Q86C09
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyl pyrophosphate synthase | protein | 351 | 75% helix, 1% strand | Q86C09 |
| B | Farnesyl pyrophosphate synthase | protein | 347 | 76% helix, 1% strand | Q86C09 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 790 | 0.75 | 0.79 | 66 | empty |
| 2 | 887 | 0.74 | 0.78 | 73 | empty |
Interfaces
1 interface between chains.
- A–B · 13 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4RYP · Crystal Structure of T. Brucei Farnesyl Diphosphate Synthase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86C09
- Elsewhere: RCSB PDB 4RYP · PDBe 4RYP · UniProt Q86C09
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