Research workbench
Human protein arginine methyltransferase 3 in complex with 1- isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-YL)ETHYL]UREA
Analyse Human protein arginine methyltransferase 3 in complex with 1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RYL
- Type
- protein
- Length
- 300 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PRMT3 protein
- UniProt
- Q8WUV3
- Ligands
- 3ZG, UNX
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PRMT3 protein | protein | 300 | 26% helix, 39% strand | Q8WUV3 |
Ligands and binding sites
- 3ZG · 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea · ligand · chains A
- UNX · Unknown atom or ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.56 | 0.78 | 36 | empty |
| 2 | 73 | 0.56 | 0.87 | 13 | 3ZG |
Compared structures
- 4RYL · Human Protein Arginine Methyltransferase 3 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUV3
- Elsewhere: RCSB PDB 4RYL · PDBe 4RYL · UniProt Q8WUV3
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