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Structure of PNOB8 parb-C

Analyse Structure of PNOB8 parb-C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RS7
Type: protein
Length: 349 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Parb-C
UniProt: O93707
Pockets: 6 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R, D, A	Parb-C	protein	87	79% helix, 0% strand	O93707
B	Parb-C	protein	88	77% helix, 0% strand	O93707

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.54	0.78	26	empty
2	82	0.45	0.80	16	empty
3	93	0.42	0.78	20	empty
4	114	0.42	0.76	16	empty
5	64	0.37	0.78	12	empty

Interfaces

6 interfaces between chains.

R–D · 2633 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 2587 Å² buried · 17 hydrogen bonds · protein-protein
D–B · 421 Å² buried · 5 hydrogen bonds · protein-protein
D–A · 329 Å² buried · 3 hydrogen bonds · protein-protein
R–B · 310 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

4RS7 · Structure of pNOB8 ParB-C · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O93707
Elsewhere: RCSB PDB 4RS7 · PDBe 4RS7 · UniProt O93707

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