Research workbench
Crystal structure of an uncoating intermediate of a EV71 recombinant virus
Analyse Crystal structure of an uncoating intermediate of a EV71 recombinant virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RS5
- Type
- protein
- Length
- 3,400 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein VP3; Capsid protein VP0; Capsid protein VP1
- UniProt
- F6KTB0
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, N, B, H, K | Capsid protein VP3 | protein | 223 | 11% helix, 32% strand | F6KTB0 |
| F, O, C, I, L | Capsid protein VP0 | protein | 236 | 10% helix, 28% strand | F6KTB0 |
| D, M, A, G, J | Capsid protein VP1 | protein | 221 | 8% helix, 32% strand | F6KTB0 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 877 | 0.79 | 0.81 | 63 | empty |
| 2 | 872 | 0.78 | 0.81 | 85 | empty |
| 3 | 557 | 0.77 | 0.84 | 60 | empty |
| 4 | 873 | 0.77 | 0.80 | 93 | empty |
| 5 | 514 | 0.76 | 0.84 | 53 | empty |
Interfaces
53 interfaces between chains.
- M–N · 3074 Ų buried · 48 hydrogen bonds · protein-protein
- E–D · 3066 Ų buried · 51 hydrogen bonds · protein-protein
- J–K · 3043 Ų buried · 44 hydrogen bonds · protein-protein
- G–H · 3024 Ų buried · 44 hydrogen bonds · protein-protein
- A–B · 2994 Ų buried · 43 hydrogen bonds · protein-protein
Compared structures
- 4RS5 · Crystal structure of an uncoating intermediate of a EV71 recombinant virus · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F6KTB0
- Elsewhere: RCSB PDB 4RS5 · PDBe 4RS5 · UniProt F6KTB0
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