Research workbench
Crystal structure and mutational analysis of the endoribonuclease from human coronavirus 229E
Analyse Crystal structure and mutational analysis of the endoribonuclease from human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RS4
- Type
- protein
- Length
- 2,042 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridylate-specific endoribonuclease
- EC
- 3.1.-.-
- UniProt
- P0C6X1
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 20% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Uridylate-specific endoribonuclease (EC 3.1.-.-) | protein | 341 | 19% helix, 30% strand | P0C6X1 |
| B | Uridylate-specific endoribonuclease (EC 3.1.-.-) | protein | 345 | 18% helix, 32% strand | P0C6X1 |
| C | Uridylate-specific endoribonuclease (EC 3.1.-.-) | protein | 332 | 20% helix, 30% strand | P0C6X1 |
| D | Uridylate-specific endoribonuclease (EC 3.1.-.-) | protein | 337 | 19% helix, 31% strand | P0C6X1 |
| F | Uridylate-specific endoribonuclease (EC 3.1.-.-) | protein | 346 | 21% helix, 34% strand | P0C6X1 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.84 | 0.93 | 33 | empty |
| 2 | 706 | 0.83 | 0.87 | 76 | empty |
| 3 | 393 | 0.81 | 0.90 | 42 | empty |
| 4 | 646 | 0.81 | 0.86 | 69 | empty |
| 5 | 831 | 0.79 | 0.82 | 109 | empty |
Interfaces
12 interfaces between chains.
- E–F · 1313 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 1285 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1269 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 1258 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1254 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4RS4 · Crystal structure and mutational analysis of the endoribonuclease from human coronavirus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C6X1
- Elsewhere: RCSB PDB 4RS4 · PDBe 4RS4 · UniProt P0C6X1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.