Research workbench
Bacterial vitamin C transporter ULAA/SGAT in P21 form
Analyse Bacterial vitamin C transporter ULAA/SGAT in P21 form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RP8
- Type
- protein
- Length
- 872 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ascorbate-specific permease iic component ulaa
- UniProt
- P39301
- Ligands
- ASC, BNG
- Pockets
- 15 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ascorbate-specific permease iic component ulaa | protein | 442 | 79% helix, 4% strand | P39301 |
| C | Ascorbate-specific permease iic component ulaa | protein | 430 | 79% helix, 4% strand | P39301 |
Ligands and binding sites
- ASC · Ascorbic acid · ligand · 2 copies · chains A, C
- BNG · nonyl beta-D-glucopyranoside · ligand · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.66 | 0.83 | 22 | empty |
| 2 | 225 | 0.66 | 0.83 | 22 | empty |
| 3 | 166 | 0.61 | 0.83 | 23 | ASC |
| 4 | 229 | 0.59 | 0.79 | 29 | BNG |
| 5 | 105 | 0.54 | 0.83 | 22 | empty |
Interfaces
1 interface between chains.
- A–C · 1443 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4RP8 · Bacterial vitamin C transporter UlaA/SgaT in P21 form · the same entry in another collection · chain A against A, TM-score 1.00
- P39301 · AlphaFold monomer V2.0 prediction for ascorbate-specific pts system eiic component… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39301
- Elsewhere: RCSB PDB 4RP8 · PDBe 4RP8 · UniProt P39301
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