Research workbench
Crystal structure of the L27 domain of discs large 1 (target id nysgrc-010766) from drosophila melanogaster bound to a potassium ion (space group P212121)
Analyse Crystal structure of the L27 domain of discs large 1 (target id nysgrc-010766)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RP3
- Type
- protein
- Length
- 181 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disks large 1 tumor suppressor protein
- UniProt
- P31007
- Ligands
- K, CL
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Disks large 1 tumor suppressor protein | protein | 91 | 77% helix, 4% strand | P31007 |
| B | Disks large 1 tumor suppressor protein | protein | 90 | 78% helix, 6% strand | P31007 |
Ligands and binding sites
- K · Potassium ion · metal · chains A
- CL · Chloride ion · ion · chains A, B
- FMT · Formic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 321 | 0.56 | 0.75 | 31 | K, CL |
Interfaces
1 interface between chains.
- A–B · 2621 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 4RP3 · Crystal Structure of the L27 Domain of Discs Large 1 (target ID NYSGRC-010766) from… · the same entry in another collection · chain A against A, TM-score 1.00
- P31007 · AlphaFold monomer V2.0 prediction for disks large 1 tumor suppressor protein (P31007) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31007
- Elsewhere: RCSB PDB 4RP3 · PDBe 4RP3 · UniProt P31007
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