Research workbench
Crystal structure of bacterial multidrug efflux transporter acrb
Analyse Crystal structure of bacterial multidrug efflux transporter acrb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IWG
- Type
- protein
- Length
- 1,006 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acrb
- UniProt
- P31224
- Pockets
- 11 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acrb | protein | 1006 | 48% helix, 18% strand | P31224 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 509 | 0.82 | 0.88 | 47 | empty |
| 2 | 371 | 0.75 | 0.86 | 51 | empty |
| 3 | 200 | 0.56 | 0.79 | 31 | empty |
| 4 | 75 | 0.53 | 0.87 | 17 | empty |
| 5 | 168 | 0.46 | 0.75 | 25 | empty |
Compared structures
- 1IWG · Crystal structure of Bacterial Multidrug Efflux transporter AcrB · the same entry in another collection · chain A against A, TM-score 1.00
- P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31224
- Elsewhere: RCSB PDB 1IWG · PDBe 1IWG · UniProt P31224
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