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Crystal structure of APC3

Analyse Crystal structure of APC3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4RG7
Type: protein
Length: 939 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division cycle protein 27 homolog
UniProt: P30260
Pockets: 14 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division cycle protein 27 homolog	protein	472	77% helix, 0% strand	P30260
B	Cell division cycle protein 27 homolog	protein	467	75% helix, 0% strand	P30260

Pockets

14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1043	0.84	0.85	114	empty
2	1003	0.78	0.80	80	empty
3	225	0.76	0.90	49	empty
4	469	0.67	0.79	73	empty
5	179	0.66	0.86	32	empty

Interfaces

1 interface between chains.

A–B · 2357 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

4RG7 · Crystal structure of APC3 · the same entry in another collection · chain A against A, TM-score 1.00
P30260 · AlphaFold monomer V2.0 prediction for cell division cycle protein 27 homolog (P30260) · a predicted model of the same protein · chain B against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30260
Elsewhere: RCSB PDB 4RG7 · PDBe 4RG7 · UniProt P30260

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