Research workbench
Crystal structure of APC3-APC16 complex
Analyse Crystal structure of APC3-APC16 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RG6
- Type
- protein
- Length
- 982 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 16
- UniProt
- P30260, Q96DE5
- Pockets
- 17 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division cycle protein 27 homolog | protein | 474 | 76% helix, 0% strand | P30260 |
| B | Cell division cycle protein 27 homolog | protein | 473 | 76% helix, 0% strand | P30260 |
| S | Anaphase-promoting complex subunit 16 | protein | 35 | 66% helix, 0% strand | Q96DE5 |
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1119 | 0.81 | 0.82 | 70 | empty |
| 2 | 1032 | 0.81 | 0.82 | 66 | empty |
| 3 | 52 | 0.71 | 0.98 | 19 | empty |
| 4 | 52 | 0.70 | 0.97 | 19 | empty |
| 5 | 261 | 0.56 | 0.77 | 39 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2970 Ų buried · 35 hydrogen bonds · protein-protein
- A–S · 1100 Ų buried · 13 hydrogen bonds · protein-protein
- B–S · 242 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4RG6 · Crystal structure of APC3-APC16 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P30260 · AlphaFold monomer V2.0 prediction for cell division cycle protein 27 homolog (P30260) · a predicted model of the same protein · chain A against A, TM-score 0.86
- Q96DE5 · AlphaFold monomer V2.0 prediction for anaphase-promoting complex subunit 16 (Q96DE5) · a predicted model of the same protein · chain S against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30260
- Every structure of UniProt Q96DE5
- Elsewhere: RCSB PDB 4RG6 · PDBe 4RG6 · UniProt P30260 · UniProt Q96DE5
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