Research workbench
Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 ångström resolution
Analyse Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 ångström… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4R9H
- Type
- protein
- Length
- 394 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-2-microglobulin
- UniProt
- P61769
- Pockets
- 5 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| B, C | Beta-2-microglobulin | protein | 98 | 0% helix, 51% strand | P61769 |
| D | Beta-2-microglobulin | protein | 98 | 0% helix, 53% strand | P61769 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.44 | 0.79 | 22 | empty |
| 2 | 119 | 0.38 | 0.74 | 24 | empty |
| 3 | 75 | 0.36 | 0.77 | 15 | empty |
| 4 | 69 | 0.34 | 0.76 | 15 | empty |
| 5 | 81 | 0.30 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–D · 631 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 543 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 443 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4R9H · Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.9 Angstrom resolution · the same entry in another collection · chain D against D, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 4R9H · PDBe 4R9H · UniProt P61769
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