Research workbench
Structure of a llama glama Fab 48A2 against human cmet
Analyse Structure of a llama glama Fab 48A2 against human cmet in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4R96
- Type
- protein
- Length
- 1,736 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Llama glama Fab 48A2 against human cmet L chain; Llama glama Fab 48A2 against human cmet…
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Llama glama Fab 48A2 against human cmet L chain | protein | 219 | 6% helix, 52% strand | — |
| E, L | Llama glama Fab 48A2 against human cmet L chain | protein | 221 | 5% helix, 47% strand | — |
| B, D, F | Llama glama Fab 48A2 against human cmet H chain | protein | 213 | 8% helix, 51% strand | — |
| H | Llama glama Fab 48A2 against human cmet H chain | protein | 217 | 3% helix, 50% strand | — |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1033 | 0.78 | 0.80 | 86 | empty |
| 2 | 800 | 0.77 | 0.81 | 92 | empty |
| 3 | 245 | 0.65 | 0.83 | 40 | empty |
| 4 | 542 | 0.62 | 0.75 | 63 | empty |
| 5 | 167 | 0.60 | 0.84 | 29 | empty |
Interfaces
13 interfaces between chains.
- L–H · 1859 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1758 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1734 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 1732 Ų buried · 12 hydrogen bonds · protein-protein
- B–H · 567 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 4R96 · Structure of a Llama Glama Fab 48A2 against human cMet · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4R96 · PDBe 4R96
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