Research workbench
Crystal structure of a uricase from bacillus fastidious
Analyse Crystal structure of a uricase from bacillus fastidious in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4R8X
- Type
- protein
- Length
- 1,257 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uricase
- EC
- 3.1.2.4
- UniProt
- C5HDG5
- Pockets
- 15 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 26% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uricase (EC 3.1.2.4) | protein | 315 | 26% helix, 39% strand | C5HDG5 |
| B | Uricase (EC 3.1.2.4) | protein | 315 | 26% helix, 38% strand | C5HDG5 |
| C | Uricase (EC 3.1.2.4) | protein | 309 | 26% helix, 39% strand | C5HDG5 |
| D | Uricase (EC 3.1.2.4) | protein | 318 | 26% helix, 39% strand | C5HDG5 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 862 | 0.80 | 0.82 | 88 | empty |
| 2 | 801 | 0.79 | 0.82 | 90 | empty |
| 3 | 999 | 0.73 | 0.76 | 98 | empty |
| 4 | 909 | 0.73 | 0.77 | 92 | empty |
| 5 | 288 | 0.66 | 0.82 | 42 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2860 Ų buried · 47 hydrogen bonds · protein-protein
- B–D · 2834 Ų buried · 45 hydrogen bonds · protein-protein
- C–D · 2743 Ų buried · 43 hydrogen bonds · protein-protein
- A–B · 2685 Ų buried · 44 hydrogen bonds · protein-protein
- B–C · 259 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4R8X · Crystal structure of a uricase from Bacillus fastidious · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C5HDG5
- Elsewhere: RCSB PDB 4R8X · PDBe 4R8X · UniProt C5HDG5
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