Research workbench
The high resolution three-dimensional solution structure of human interleukin-4 determined by multi-dimensional heteronuclear magnetic resonance spectroscopy
Analyse The high resolution three-dimensional solution structure of human interleukin-4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ITI
- Type
- protein
- Length
- 133 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-4
- UniProt
- P05112
- Pockets
- 2 · best druggability 0.52
Structure
solution nmr · 1 distinct chain · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-4 | protein | 133 | 59% helix, 3% strand | P05112 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.52 | 0.84 | 15 | empty |
| 2 | 59 | 0.34 | 0.77 | 12 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1ITI · The high resolution three-dimensional solution structure of human interleukin-4… · the same entry in another collection · chain A against A, TM-score 1.00
- P05112 · AlphaFold monomer V2.0 prediction for interleukin-4 (P05112) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05112
- Elsewhere: RCSB PDB 1ITI · PDBe 1ITI · UniProt P05112
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