Research workbench
Crystal structure of an antigen-binding fragment from a humanized version of the anti-human fas antibody HFE7A
Analyse Crystal structure of an antigen-binding fragment from a humanized version of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IT9
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Humanized antibody HFE7A, light chain; Humanized antibody HFE7A, heavy chain
- UniProt
- Q6GMV9, Q6PJA4
- Pockets
- 5 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Humanized antibody HFE7A, light chain | protein | 214 | 5% helix, 48% strand | Q6GMV9 |
| H | Humanized antibody HFE7A, heavy chain | protein | 219 | 5% helix, 53% strand | Q6PJA4 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 74 | 0.58 | 0.89 | 20 | empty |
| 2 | 279 | 0.52 | 0.74 | 42 | empty |
| 3 | 88 | 0.39 | 0.77 | 19 | empty |
| 4 | 73 | 0.31 | 0.74 | 16 | empty |
| 5 | 63 | 0.28 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- L–H · 1841 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1IT9 · Crystal structure of an antigen-binding fragment from a humanized version of the… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GMV9
- Every structure of UniProt Q6PJA4
- Elsewhere: RCSB PDB 1IT9 · PDBe 1IT9 · UniProt Q6GMV9 · UniProt Q6PJA4
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